“There is a lot of enthusiasm to participate,” among the workers, Bonten says. A century-old tuberculosis vaccine, bacillus Calmette-Guerin, or BCG vaccine, could... The team decided not to use actual infection with coronavirus as the study outcome, but “unplanned absenteeism.” “We don’t have a large budget and it won’t be feasible to visit the sick professionals at home,” Bonten says. Looking at absenteeism has the advantage that any beneficial effects of the BCG vaccine on influenza and other infections may be captured as well, he says.Although the study is randomized, participants will likely know if they got the vaccine instead of a placebo. A vaccine that’s been used to prevent tuberculosis is being given to health-care workers in Melbourne to see if it will protect them against the coronavirus.
Once the pathogen is eliminated, a small portion of these pathogen-specific cells transform into memory cells that speed up T cell and B cell production the next time the same pathogen attacks. They will recruit 1000 health care workers in eight Dutch hospitals who will either receive the vaccine, called bacillus Calmette-Guérin (BCG), or a placebo.Vaccines generally raise immune responses specific to a targeted pathogen, such as antibodies that bind and neutralize one type of virus but not others. Researchers in four countries will soon start a clinical trial of an unorthodox approach to the new coronavirus. We've received your submission.Coronavirus death rates are nearly six times lower in countries that use a nearly century-old tuberculosis vaccine, The study, conducted by researchers at the Johns Hopkins Bloomberg School of Public Health, found that the COVID-19 mortality rate among countries that use the Bacillus Calmette-Guérin (BCG) vaccination was 5.8 times lower than in those that do not.“Demonstration that exposure to BCG vaccination can ameliorate severe COVID-19 disease and lower mortality could rationalize a therapeutic or preventive strategy that can have immediately deployable global impact,” the researchers wrote.“Therefore, using existing publicly available data, we examined at the ecological level whether country-level COVID-19 mortality was associated with BCG use in national immunization schedules.”The vaccine, first administered to a human in 1921 and primarily used to protect against tuberculosis, is undergoing clinical trials to test its ability to ward off COVID-19.Using the mortality per 1 million residents of each country with sufficient data, researchers estimated the coronavirus fatality rate from the 50 countries with the highest number of cases.After accounting for the economic status of the countries and their elderly populations — both of which contribute to death rates — “the intriguing observation of a significant association between BCG use and lower COVID-19-attributable mortality remained discernable,” the researchers said.The researchers said the findings “warrant deeper epidemiological scrutiny and prospective evaluation in individually randomized trials.”The WHO will “evaluate the evidence when it is available,” and does not currently recommend the vaccination for the prevention of COVID-19, it said.Studies like the Johns Hopkins one, which has yet to be peer-reviewed, “are prone to significant bias from many confounders, including differences in national demographics and disease burden, testing rates for COVID-19 virus infections, and the stage of the pandemic in each country,” the organization said.Researchers at the Murdoch Children’s Research Institute in Melbourne, Australia, “I think BCG vaccine is a bit of the equivalent of a Hail Mary pass,” Dr. William Schaffner, an infectious disease specialist at the Vanderbilt University School of Medicine, Kwangmoozaa/iStock
Vaccines are based on this mechanism of immunity.The innate immune system, composed of white blood cells such as macrophages, natural killer cells, and neutrophils, was supposed to have no such memory. Post was not sent - check your email addresses!
He is planning to start a similar study in the Netherlands soon. Philip Supply holds the original test tube used to develop the BCG vaccine.At death's door: Photo shows firefighters trying to get into warehouse just before Beirut blast But BCG may also increase the ability of the immune system to fight off pathogens other than the TB bacterium, according to clinical and observational studies published over several decades by Danish researchers Peter Aaby and Christine Stabell Benn, who live and work in Guinea-Bissau. The trial was designed before the new coronavirus emerged, but the pandemic may reveal BCG’s broad effects more clearly, Netea says.For the health care worker study, Neeta teamed up with epidemiologist and microbiologist Marc Bonten of UMC Utrecht. Mihai Netea, an infectious disease specialist at Radboud University Medical Center, discovered that the vaccine may defy textbook knowledge of how immunity works.When a pathogen enters the body, white blood cells of the “innate” arm of the immune system attack it first; they may handle up to 99% of infections.
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